Okay, this has been bugging me. The geek demon’s been sitting on my shoulder, and won’t allow the question to die. So, today, Google and I did some research.
First, I discovered that jaguar fossils have been found in caves in eastern Tennessee. Check out the map on this page. Notice the dot on the Tennessee/North Carolina line.
Finally, I found this at Google Books: Pleistocene Mammals of North America. It lists South Carolina, as well as Florida, Georgia, and Tennessee. I was unfamiliar with some of the chronological terms, so I looked them up at Wikipedia. The Irvingtonian was 1.8 million to 300,000 BP and the Rancholabrean 300,000 to 11,000 BP.
Besides, these, I found several references to jaguars in Oregon, Washington, Nebraska, Pennsylvania, and Maryland.
Anyway, it was a very long time ago, but jaguars did roam in the Carolinas, though, given the sparsity of the evidence, probably not in large numbers.